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Tianeptine intermediate cas 66981-73-5 cas 1224690-84-9 

  Category : Chemicals->active pharmaceutical ingredient

     
Tianeptine intermediate cas 66981-73-5 cas 1224690-84-9
       

  Product Specification
 
  Country  CN

 

    Product Detail
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Chemical&nbsp;Name: TIANEPTINE<br />
Molecular&nbsp;Formula: C21H25ClN2O4S<br />
Formula&nbsp;Weight: 436.95
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CAS&nbsp;No.: 66981-73-5
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<img src="http://i.bosscdn.com/product/73/2e/04/cec35bcc80359e75098aed040d.gif" title="66981-73-5" alt="66981-73-5" />
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Chemical Name: tianeptine sulfate
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Molecular Formula: 2(C21H25ClN2O4S).H2SO4.2(H2O)
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Formula Weight:
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CAS No.: &nbsp;1224690-84-9
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<img src="http://i.bosscdn.com/product/ad/79/bc/5522be3c455d06c9995987641b.jpg" title="1224690-84-9" alt="1224690-84-9" />
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Tianeptine&nbsp;has&nbsp;antidepressant&nbsp;and&nbsp;anxiolytic&nbsp;effects&nbsp;with&nbsp;a&nbsp;relative&nbsp;lack&nbsp;of&nbsp;sedative,&nbsp;anticholinergic,&nbsp;and&nbsp;cardiovascular&nbsp;side&nbsp;effects.&nbsp;It&nbsp;has&nbsp;been&nbsp;found&nbsp;to&nbsp;act&nbsp;as&nbsp;an&nbsp;atypical&nbsp;agonist&nbsp;of&nbsp;the&nbsp;μ-opioid&nbsp;receptor&nbsp;with&nbsp;clinically&nbsp;negligible&nbsp;effects&nbsp;on&nbsp;the&nbsp;δ-&nbsp;and&nbsp;κ-opioid&nbsp;receptors.&nbsp;μ-Opioid&nbsp;receptor&nbsp;agonists&nbsp;typically&nbsp;induce&nbsp;euphoria,&nbsp;and&nbsp;in&nbsp;accordance,&nbsp;tianeptine&nbsp;does&nbsp;so&nbsp;at&nbsp;high&nbsp;doses&nbsp;well&nbsp;above&nbsp;the&nbsp;normal&nbsp;therapeutic&nbsp;range.<br />
Tianeptine&nbsp;is&nbsp;an&nbsp;antidepressant&nbsp;agent&nbsp;with&nbsp;a&nbsp;novel&nbsp;neurochemical&nbsp;profile.&nbsp;It&nbsp;increases&nbsp;serotonin&nbsp;(5-hydroxytryptamine;&nbsp;5-HT)&nbsp;uptake&nbsp;in&nbsp;the&nbsp;brain&nbsp;(in&nbsp;contrast&nbsp;with&nbsp;most&nbsp;antidepressant&nbsp;agents)&nbsp;and&nbsp;reduces&nbsp;stress-induced&nbsp;atrophy&nbsp;of&nbsp;neuronal&nbsp;dendrites.&nbsp;Like&nbsp;the&nbsp;selective&nbsp;serotonin&nbsp;reuptake&nbsp;inhibitors&nbsp;(SSRIs)&nbsp;and&nbsp;in&nbsp;contrast&nbsp;with&nbsp;most&nbsp;tricyclic&nbsp;antidepressant&nbsp;agents,&nbsp;tianeptine&nbsp;does&nbsp;not&nbsp;appear&nbsp;to&nbsp;be&nbsp;associated&nbsp;with&nbsp;adverse&nbsp;cognitive,&nbsp;psychomotor,&nbsp;sleep,&nbsp;cardiovascular&nbsp;or&nbsp;bodyweight&nbsp;effects&nbsp;and&nbsp;has&nbsp;a&nbsp;low&nbsp;propensity&nbsp;for&nbsp;abuse.&nbsp;Tianeptine&nbsp;has&nbsp;a&nbsp;comparatively&nbsp;favourable&nbsp;pharmacokinetic&nbsp;profile.&nbsp;It&nbsp;is&nbsp;not&nbsp;subject&nbsp;to&nbsp;first-pass&nbsp;hepatic&nbsp;metabolism,&nbsp;has&nbsp;high&nbsp;bioavailability&nbsp;and&nbsp;limited&nbsp;distribution,&nbsp;and&nbsp;is&nbsp;rapidly&nbsp;eliminated.&nbsp;While&nbsp;this&nbsp;offers&nbsp;advantages&nbsp;for&nbsp;tianeptine&nbsp;over&nbsp;the&nbsp;tricyclic&nbsp;antidepressant&nbsp;agents&nbsp;in&nbsp;terms&nbsp;of&nbsp;dose&nbsp;titration,&nbsp;treatment&nbsp;changes&nbsp;and&nbsp;potential&nbsp;drug&nbsp;interactions,&nbsp;its&nbsp;rapid&nbsp;elimination&nbsp;makes&nbsp;adherence&nbsp;to&nbsp;dosage&nbsp;schedules&nbsp;more&nbsp;important.&nbsp;
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