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Crizotinib intermediate cas 877399-00-3 

  Category : Chemicals->active pharmaceutical ingredient

     
Crizotinib intermediate cas 877399-00-3
       

  Product Specification
 
  Country  CN

 

    Product Detail
  <p class="MsoNormal">
Chemical&nbsp;Name: (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine<br />
Molecular&nbsp;Formula: C13H10BrCl2FN2O<br />
Formula&nbsp;Weight: 380<br />
CAS&nbsp;No.: 877399-00-3
</p>
<p class="MsoNormal">
<img src="http://i.bosscdn.com/product/c6/10/ad/663afa7786dee0a22d5b39b642.gif" title="877399-00-3" alt="877399-00-3" />
</p>
<p class="MsoNormal">
<br />
Chemical&nbsp;Name: Crizotinib<br />
Molecular&nbsp;Formula: C21H22Cl2FN5O<br />
Formula&nbsp;Weight: 450.343<br />
CAS&nbsp;No.: 877399-52-5
</p>
<p class="MsoNormal">
<img src="http://i.bosscdn.com/product/25/2e/7d/b78b53c86f277dde05a26f390c.gif" width="200" height="110" title="877399-52-5" alt="877399-52-5" />
</p>
<p class="MsoNormal">
<br />
Crizotinib&nbsp;is&nbsp;an&nbsp;oral&nbsp;receptor&nbsp;tyrosine&nbsp;kinase&nbsp;inhibitor.&nbsp;The&nbsp;molecular&nbsp;formula&nbsp;for&nbsp;crizotinib&nbsp;is&nbsp;C21H22Cl2FN5O.&nbsp;The&nbsp;molecular&nbsp;weight&nbsp;is&nbsp;450.34&nbsp;Daltons<br />
Potent&nbsp;inhibitor&nbsp;of&nbsp;c-MET&nbsp;and&nbsp;anaplastic&nbsp;lymphoma&nbsp;kinase&nbsp;(ALK)&nbsp;(cell&nbsp;IC50&nbsp;values&nbsp;are&nbsp;8.0&nbsp;and&nbsp;20&nbsp;nM&nbsp;respectively).&nbsp;Selective&nbsp;for&nbsp;c-MET&nbsp;and&nbsp;ALK&nbsp;against&nbsp;&gt;120&nbsp;different&nbsp;kinases.&nbsp;Displays&nbsp;antitumor&nbsp;efficacy&nbsp;in&nbsp;multiple&nbsp;tumor&nbsp;models;&nbsp;inhibits&nbsp;c-MET-dependent&nbsp;proliferation,&nbsp;migration&nbsp;and&nbsp;invasion&nbsp;of&nbsp;human&nbsp;tumor&nbsp;cells&nbsp;in&nbsp;vitro.&nbsp;Orally&nbsp;bioavailable.
</p>pharmachemm.com

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