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Cas 6108-05-0 API and intermediate 

  Category : Chemicals->Pharmaceutical->pharmaceutical

     
Cas 6108-05-0 API and intermediate
       

  Product Specification
 
  Country  CN

 

    Product Detail
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CAS NO.: &nbsp;6108-05-0
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Standard: BP,CP,USP
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Molecular Formula: C14H25ClN2O2
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Molecular Weight: 288.81
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Description: White crystal or crystalline powder
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Package: 25KG/drums
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Chemical names, synonyms:
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2`,6`-acetoxylidide,2-(diethylamino)-,hydrochloride,hydrate
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acetamide,2-(diethylamino)-n-(2,6-dimethylphenyl)-,monohydrochloride,monoh
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diethylaminoacet-2,6-xylididehydrochloridemonohydrate
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Minimum purity: 99%
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<img src="http://i.bosscdn.com/product/f7/43/1c/d06124bb17e09edc9d59a09ab6.gif" title="6108-05-0" alt="6108-05-0" />
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Cas 6108-05-0&nbsp;is&nbsp;also&nbsp;the&nbsp;most&nbsp;important&nbsp;class-1b&nbsp;antiarrhythmic&nbsp;drug;&nbsp;it&nbsp;is&nbsp;used&nbsp;intravenously&nbsp;for&nbsp;the&nbsp;treatment&nbsp;of&nbsp;ventricular&nbsp;arrhythmias&nbsp;(for&nbsp;acute&nbsp;myocardial&nbsp;infarction,&nbsp;digoxin&nbsp;poisoning,&nbsp;cardioversion,&nbsp;or&nbsp;cardiac&nbsp;catheterization)&nbsp;if&nbsp;amiodarone&nbsp;is&nbsp;not&nbsp;available&nbsp;or&nbsp;contraindicated.&nbsp;Cas 6108-05-0&nbsp;should&nbsp;be&nbsp;given&nbsp;for&nbsp;this&nbsp;indication&nbsp;after&nbsp;defibrillation,&nbsp;CPR,&nbsp;and&nbsp;vasopressors&nbsp;have&nbsp;been&nbsp;initiated.&nbsp;A&nbsp;routine&nbsp;preventative&nbsp;dose&nbsp;is&nbsp;no&nbsp;longer&nbsp;recommended&nbsp;after&nbsp;a&nbsp;myocardial&nbsp;infarction&nbsp;as&nbsp;the&nbsp;overall&nbsp;benefit&nbsp;is&nbsp;not&nbsp;convincing.<br />
6108-05-0&nbsp;Hydrochloride&nbsp;is&nbsp;the&nbsp;hydrochloride&nbsp;salt&nbsp;from&nbsp;of&nbsp;6108-05-0,&nbsp;an&nbsp;aminoethylamide&nbsp;and&nbsp;a&nbsp;prototypical&nbsp;member&nbsp;of&nbsp;the&nbsp;amide&nbsp;class&nbsp;anesthetics.&nbsp;6108-05-0&nbsp;interacts&nbsp;with&nbsp;voltage-gated&nbsp;Na+&nbsp;channels&nbsp;in&nbsp;the&nbsp;nerve&nbsp;cell&nbsp;membrane&nbsp;and&nbsp;blocks&nbsp;the&nbsp;transient&nbsp;increase&nbsp;in&nbsp;permeability&nbsp;of&nbsp;excitable&nbsp;membranes&nbsp;to&nbsp;Na+.&nbsp;This&nbsp;prevents&nbsp;the&nbsp;generation&nbsp;and&nbsp;conduction&nbsp;of&nbsp;nerve&nbsp;impulses&nbsp;and&nbsp;produces&nbsp;a&nbsp;reversible&nbsp;loss&nbsp;of&nbsp;sensation.&nbsp;6108-05-0&nbsp;hydrochloride&nbsp;also&nbsp;exhibits&nbsp;class&nbsp;IB&nbsp;antiarrhythmic&nbsp;effects.&nbsp;The&nbsp;agent&nbsp;decreases&nbsp;the&nbsp;flow&nbsp;of&nbsp;sodium&nbsp;ions&nbsp;into&nbsp;myocardial&nbsp;tissue,&nbsp;especially&nbsp;on&nbsp;the&nbsp;Purkinje&nbsp;network,&nbsp;during&nbsp;phase&nbsp;0&nbsp;of&nbsp;the&nbsp;action&nbsp;potential,&nbsp;thereby&nbsp;decreasing&nbsp;depolarization,&nbsp;automaticity&nbsp;and&nbsp;excitability
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