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Epalrestat intermediate cas 5718-83-2 

  Category : Chemicals->active pharmaceutical ingredient

     
Epalrestat intermediate cas 5718-83-2
       

  Product Specification
 
  Country  CN

 

    Product Detail
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Chemical&nbsp;Name: Rhodanine-3-acetic&nbsp;acid<br />
Molecular&nbsp;Formula: C5H5NO3S2<br />
Formula&nbsp;Weight: 191.23<br />
CAS&nbsp;No.: 5718-83-2
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<img src="http://i.bosscdn.com/product/97/fa/ed/b96d53c971deb4e571274f3136.gif" title="5718-83-2" alt="5718-83-2" />
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Chemical Name: Epalrestat
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Molecular Formula: C15H13NO3S2
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Formula Weight: 319.4
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CAS No.: 82159-09-9
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&nbsp;<img src="http://i.bosscdn.com/product/be/25/f0/5672416dccf298d9e961576d53.gif" title="82159-09-9" alt="82159-09-9" />
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Chemical Name: alpha-Methylcinnamaldehyde
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Molecular Formula: C10H10O
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Formula Weight: 146.19
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CAS No.: 101-39-3
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<img src="http://i.bosscdn.com/product/38/da/3f/6b67fe7d53b1d6b0d998123600.gif" title="101-39-3" alt="101-39-3" /><br />
Epalrestat&nbsp;is&nbsp;a&nbsp;carboxylic&nbsp;acid&nbsp;derivative&nbsp;and&nbsp;a&nbsp;noncompetitive&nbsp;and&nbsp;reversible&nbsp;aldose&nbsp;reductase&nbsp;inhibitor&nbsp;used&nbsp;for&nbsp;the&nbsp;treatment&nbsp;of&nbsp;diabetic&nbsp;neuropathy,&nbsp;which&nbsp;is&nbsp;one&nbsp;of&nbsp;the&nbsp;most&nbsp;common&nbsp;long-term&nbsp;complications&nbsp;in&nbsp;patients&nbsp;with&nbsp;diabetes&nbsp;mellitus.&nbsp;It&nbsp;reduces&nbsp;the&nbsp;accumulation&nbsp;of&nbsp;intracellular&nbsp;sorbitol&nbsp;which&nbsp;is&nbsp;believed&nbsp;to&nbsp;be&nbsp;the&nbsp;cause&nbsp;of&nbsp;diabetic&nbsp;neuropathy,&nbsp;retinopathy&nbsp;and&nbsp;nephropathy.&nbsp;It&nbsp;is&nbsp;well&nbsp;tolerated,&nbsp;with&nbsp;the&nbsp;most&nbsp;commonly&nbsp;reported&nbsp;adverse&nbsp;effects&nbsp;being&nbsp;gastrointestinal&nbsp;issues&nbsp;such&nbsp;as&nbsp;nausea&nbsp;and&nbsp;vomiting,&nbsp;as&nbsp;well&nbsp;as&nbsp;increases&nbsp;in&nbsp;certain&nbsp;liver&nbsp;enzymes.&nbsp;Chemically,&nbsp;epalrestat&nbsp;is&nbsp;unusual&nbsp;in&nbsp;that&nbsp;it&nbsp;is&nbsp;a&nbsp;drug&nbsp;that&nbsp;contains&nbsp;a&nbsp;rhodanine&nbsp;group.&nbsp;Aldose&nbsp;reductase&nbsp;is&nbsp;the&nbsp;key&nbsp;enzyme&nbsp;in&nbsp;the&nbsp;polyol&nbsp;pathway&nbsp;whose&nbsp;enhanced&nbsp;activity&nbsp;is&nbsp;the&nbsp;basis&nbsp;of&nbsp;diabetic&nbsp;neuropathy.&nbsp;Aldose&nbsp;reductase&nbsp;inhibitors&nbsp;(ARI)&nbsp;target&nbsp;this&nbsp;enzyme.&nbsp;Out&nbsp;of&nbsp;the&nbsp;many&nbsp;ARIs&nbsp;developed,&nbsp;ranirestat&nbsp;and&nbsp;fidarestat&nbsp;are&nbsp;in&nbsp;the&nbsp;trial&nbsp;stage.&nbsp;Others&nbsp;have&nbsp;been&nbsp;discarded&nbsp;due&nbsp;to&nbsp;unacceptable&nbsp;adverse&nbsp;effects&nbsp;or&nbsp;weak&nbsp;efficacy.&nbsp;Epalrestat&nbsp;is&nbsp;the&nbsp;only&nbsp;ARI&nbsp;commercially&nbsp;available.&nbsp;It&nbsp;is&nbsp;easily&nbsp;absorbed&nbsp;into&nbsp;the&nbsp;neural&nbsp;tissue&nbsp;and&nbsp;inhibits&nbsp;the&nbsp;enzyme&nbsp;with&nbsp;minimum&nbsp;side&nbsp;effects.
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