Sign In Join Help
 
JinanJianfengChemicalCo.,Ltd.

 
 
Recommended Results 
 
Lapatinib API Lapatinib Intermedicate cas 231277-92-2 

  Category : Chemicals->Pharmaceutical->pharmaceutical

     
Lapatinib API Lapatinib Intermedicate cas 231277-92-2
       

  Product Specification
 
  Country  CN

 

    Product Detail
  <p class="MsoNormal">
Product Name: Lapatinib
</p>
<p class="MsoNormal">
CAS NO.: 231277-92-2
</p>
<p class="MsoNormal">
Molecular Formula: C29H26ClFN4O4S
</p>
<p class="MsoNormal">
Molecular Weight: 581.0575432
</p>
<p class="MsoNormal">
Description: White crystal or crystalline powder
</p>
<p class="MsoNormal">
Package: 25KG/drums
</p>
<p class="MsoNormal">
Chemical names, synonyms: Lapatinib(TINIBS), Lapatinib free base, GSK572016, GW 57201, Lapatinib(ditosylate salt), Lapatinib ditosylate
</p>
<p class="MsoNormal">
Minimum purity: 99%
</p>
<p class="MsoNormal">
<br />
</p>
<p class="MsoNormal">
<img src="http://i.bosscdn.com/product/21/0f/b2/6cb51f3de137d854f89efec8e5.gif" title="Lapatinib 231277-92-2" alt="Lapatinib 231277-92-2" />
</p>
<p class="MsoNormal">
<br />
</p>
<p class="MsoNormal">
Lapatinib&nbsp;is&nbsp;a&nbsp;synthetic,&nbsp;orally-active&nbsp;quinazoline&nbsp;with&nbsp;potential&nbsp;antineoplastic&nbsp;activity.&nbsp;Lapatinib&nbsp;reversibly&nbsp;blocks&nbsp;phosphorylation&nbsp;of&nbsp;the&nbsp;epidermal&nbsp;growth&nbsp;factor&nbsp;receptor&nbsp;(EGFR),&nbsp;ErbB2,&nbsp;and&nbsp;the&nbsp;Erk-1&nbsp;and-2&nbsp;and&nbsp;AKT&nbsp;kinases;&nbsp;it&nbsp;also&nbsp;inhibits&nbsp;cyclin&nbsp;D&nbsp;protein&nbsp;levels&nbsp;in&nbsp;human&nbsp;tumor&nbsp;cell&nbsp;lines&nbsp;and&nbsp;xenografts.&nbsp;EGFR&nbsp;and&nbsp;ErbB2&nbsp;have&nbsp;been&nbsp;implicated&nbsp;in&nbsp;the&nbsp;growth&nbsp;of&nbsp;various&nbsp;tumor&nbsp;types.&nbsp;Check&nbsp;for&nbsp;active&nbsp;clinical&nbsp;trials&nbsp;or&nbsp;closed&nbsp;clinical&nbsp;trials&nbsp;using&nbsp;this&nbsp;agent.<br />
Lapatinib&nbsp;is&nbsp;an&nbsp;anti-cancer&nbsp;drug&nbsp;developed&nbsp;by&nbsp;GlaxoSmithKline&nbsp;(GSK)&nbsp;as&nbsp;a&nbsp;treatment&nbsp;for&nbsp;solid&nbsp;tumours&nbsp;such&nbsp;as&nbsp;breast&nbsp;and&nbsp;lung&nbsp;cancer.&nbsp;It&nbsp;was&nbsp;approved&nbsp;by&nbsp;the&nbsp;FDA&nbsp;on&nbsp;March&nbsp;13,&nbsp;2007,&nbsp;for&nbsp;use&nbsp;in&nbsp;patients&nbsp;with&nbsp;advanced&nbsp;metastatic&nbsp;breast&nbsp;cancer&nbsp;in&nbsp;conjunction&nbsp;with&nbsp;the&nbsp;chemotherapy&nbsp;drug&nbsp;Capecitabine.&nbsp;Lapatinib&nbsp;is&nbsp;human&nbsp;epidermal&nbsp;growth&nbsp;factor&nbsp;receptor&nbsp;type&nbsp;2&nbsp;(HER2/ERBB2)&nbsp;and&nbsp;epidermal&nbsp;growth&nbsp;factor&nbsp;receptor&nbsp;(HER1/EGFR/ERBB1)&nbsp;tyrosine&nbsp;kinases&nbsp;inhibitor.&nbsp;It&nbsp;binds&nbsp;to&nbsp;the&nbsp;intracellular&nbsp;phosphorylation&nbsp;domain&nbsp;to&nbsp;prevent&nbsp;receptor&nbsp;autophosphorylation&nbsp;upon&nbsp;ligand&nbsp;binding.
</p>
<p>
<br />
</p>pharmachemm.com

  More Products from this Supplier
 
Tetracaine base api tetracaine base intermediate cas 94-24-6

Tetracaine base api tetracaine base intermediate cas 94-24-6
Fenspiride base cas 5053-06-5

Fenspiride base cas 5053-06-5
Cholesteryl chloride powder cas 910-31-6

Cholesteryl chloride powder cas 910-31-6
Tianeptine sodium salt cas 30123-17-2

Tianeptine sodium salt cas 30123-17-2
 
   


[ Back Products Catalog ]

Commerce Member:
Please log in your ID and password, we will later fill in relating info.
 
ID: Password: Remember my ID on this computer
Complete this form below to send out your enquiries.
All enquiries will be automatically sent to the company you want to develop.
Subject
Content (Don't input Company Name, E-Mail, Phone Number, Fax Number, and URL)
   

 


Company Profile:
* Company Name
*E-mail
*Country
*Contact Person
URL
*Phone
 - -
Fax
 - -
*Postal code
*City
*Street Address
*Business Nature
 Distributor   Exporter Importer Manufacturer
Whole Sale Retailer  Reseller Retrofitter User
Others, please specify:
*Security Code
Enter the security code.


Site Map l   Privacy Policy l Company Profile l Corporate Proposal l Contact Us l Help l Advertise With Us l  World Trade Link
    .