Sign In Join Help
 
JinanJianfengChemicalCo.,Ltd.

 
 
Recommended Results 
 
Trelagliptin CAS 865759-25-7 and SYR-472 

  Category : Chemicals->Pharmaceutical->pharmaceutical

     
Trelagliptin CAS 865759-25-7 and SYR-472
       

  Product Specification
 
  Country  CN

 

    Product Detail
  <p class="MsoNormal">
Chemical Name: SYR-472
</p>
<p class="MsoNormal">
SYR-472 succinate
</p>
<p class="MsoNormal">
Trelagliptin Succinate (SYR-472)
</p>
<p class="MsoNormal">
SYR 111472 succinate
</p>
<p class="MsoNormal">
Trelagliptin succinat
</p>
<p class="MsoNormal">
Molecular Formula: C22H26FN5O6
</p>
<p class="MsoNormal">
Formula Weight: 475.4701432
</p>
<p class="MsoNormal">
CAS No.: 1029877-94-8
</p>
<p class="MsoNormal">
<img src="http://i.bosscdn.com/product/41/68/bb/d6cabbd2c989afbe88282c4984.gif" width="300" height="146" title="1029877-94-8" alt="1029877-94-8" />
</p>
<p class="MsoNormal">
Chemical Name: Trelagliptin<br />
Molecular Formula: C18H20FN5O2<br />
Formula Weight: 357.3821032<br />
CAS No.: 865759-25-7<br />
MOL File: Mol file
</p>
<p class="MsoNormal">
<img src="http://i.bosscdn.com/product/4b/78/92/e07d7850a3cca832005fd1dd63.gif" width="280" height="165" title="865759-25-7" alt="865759-25-7" />
</p>
<p class="MsoNormal">
<br />
</p>
<p class="MsoNormal">
<br />
</p>
<p class="MsoNormal">
Trelagliptin&nbsp;(Zafatek)&nbsp;is&nbsp;an&nbsp;orally&nbsp;active&nbsp;dipeptidyl&nbsp;peptidase&nbsp;(DPP)-4&nbsp;inhibitor&nbsp;developed&nbsp;by&nbsp;Takeda&nbsp;and&nbsp;approved&nbsp;in&nbsp;Japan&nbsp;for&nbsp;the&nbsp;treatment&nbsp;of&nbsp;type&nbsp;2&nbsp;diabetes&nbsp;mellitus&nbsp;(T2DM).&nbsp;Unlike&nbsp;other&nbsp;approved&nbsp;agents&nbsp;of&nbsp;its&nbsp;class,&nbsp;which&nbsp;are&nbsp;usually&nbsp;administered&nbsp;once&nbsp;daily,&nbsp;trelagliptin&nbsp;can&nbsp;be&nbsp;administered&nbsp;once&nbsp;weekly.&nbsp;Phase&nbsp;II&nbsp;development&nbsp;of&nbsp;trelagliptin&nbsp;was&nbsp;discontinued&nbsp;in&nbsp;the&nbsp;USA&nbsp;and&nbsp;EU,&nbsp;as&nbsp;Takeda&nbsp;considered&nbsp;that&nbsp;the&nbsp;costs&nbsp;associated&nbsp;with&nbsp;obtaining&nbsp;approval&nbsp;in&nbsp;these&nbsp;markets&nbsp;were&nbsp;prohibitive.&nbsp;This&nbsp;article&nbsp;summarizes&nbsp;the&nbsp;milestones&nbsp;in&nbsp;the&nbsp;development&nbsp;of&nbsp;trelagliptin&nbsp;leading&nbsp;to&nbsp;this&nbsp;first&nbsp;approval&nbsp;for&nbsp;T2DM.<br />
Shipping&nbsp;Condition:&nbsp;Shipped&nbsp;under&nbsp;ambient&nbsp;temperature&nbsp;as&nbsp;non-hazardous&nbsp;chemical.&nbsp;This&nbsp;product&nbsp;is&nbsp;stable&nbsp;enough&nbsp;for&nbsp;a&nbsp;few&nbsp;weeks&nbsp;during&nbsp;ordinary&nbsp;shipping&nbsp;and&nbsp;time&nbsp;spent&nbsp;in&nbsp;Customs.<br />
Storage&nbsp;Condition:&nbsp;Dry,&nbsp;dark&nbsp;and&nbsp;at&nbsp;0&nbsp;-&nbsp;4&nbsp;C&nbsp;for&nbsp;short&nbsp;term&nbsp;(days&nbsp;to&nbsp;weeks)&nbsp;or&nbsp;-20&nbsp;C&nbsp;for&nbsp;long&nbsp;term&nbsp;(months&nbsp;to&nbsp;years).<br />
Solubility:&nbsp;Soluble&nbsp;in&nbsp;DMSO,&nbsp;not&nbsp;in&nbsp;water<br />
Shelf&nbsp;Life:&nbsp;&gt;2&nbsp;years&nbsp;if&nbsp;stored&nbsp;properly<br />
Drug&nbsp;Formulation:&nbsp;This&nbsp;drug&nbsp;may&nbsp;be&nbsp;formulated&nbsp;in&nbsp;DMSO<br />
Stock&nbsp;Solution&nbsp;Storage:&nbsp;0&nbsp;-&nbsp;4&nbsp;C&nbsp;for&nbsp;short&nbsp;term&nbsp;(days&nbsp;to&nbsp;weeks),&nbsp;or&nbsp;-20&nbsp;C&nbsp;for&nbsp;long&nbsp;term&nbsp;(months<br />
relagliptin,&nbsp;also&nbsp;known&nbsp;as&nbsp;SYR-472,&nbsp;is&nbsp;a&nbsp;long&nbsp;acting&nbsp;dipeptidyl&nbsp;peptidase-4&nbsp;(DPP-4)&nbsp;inhibitor&nbsp;that&nbsp;is&nbsp;being&nbsp;developed&nbsp;by&nbsp;Takeda&nbsp;for&nbsp;the&nbsp;treatment&nbsp;of&nbsp;type&nbsp;2&nbsp;diabetes&nbsp;(T2D).&nbsp;Once-weekly&nbsp;SYR-472&nbsp;treatment&nbsp;produced&nbsp;clinically&nbsp;and&nbsp;statistically&nbsp;significant&nbsp;improvements&nbsp;in&nbsp;glycaemic&nbsp;control&nbsp;in&nbsp;patients&nbsp;with&nbsp;type&nbsp;2&nbsp;diabetes.&nbsp;It&nbsp;was&nbsp;well&nbsp;tolerated&nbsp;and&nbsp;might&nbsp;be&nbsp;a&nbsp;new&nbsp;treatment&nbsp;option&nbsp;for&nbsp;patients&nbsp;with&nbsp;this&nbsp;disease.&nbsp;
</p>
<p class="MsoNormal">
&nbsp;
</p>
<p>
<br />
</p>pharmachemm.com

  More Products from this Supplier
 
Prilocaine hcl api Prilocaine hcl intermediate cas 1786-81-8

Prilocaine hcl api Prilocaine hcl intermediate cas 1786-81-8
Pregabalin api pregabalin intermediate cas 148553-50-8

Pregabalin api pregabalin intermediate cas 148553-50-8
Ibrutinib api cas 936563-96-1 Ibrutinib intermediate

Ibrutinib api cas 936563-96-1 Ibrutinib intermediate
Diazapam api Diazapam intermediate cas 439-14-5

Diazapam api Diazapam intermediate cas 439-14-5
 
   


[ Back Products Catalog ]

Commerce Member:
Please log in your ID and password, we will later fill in relating info.
 
ID: Password: Remember my ID on this computer
Complete this form below to send out your enquiries.
All enquiries will be automatically sent to the company you want to develop.
Subject
Content (Don't input Company Name, E-Mail, Phone Number, Fax Number, and URL)
   

 


Company Profile:
* Company Name
*E-mail
*Country
*Contact Person
URL
*Phone
- -
Fax
- -
*Postal code
*City
*Street Address
*Business Nature
Distributor   Exporter Importer Manufacturer
Whole Sale Retailer  Reseller Retrofitter User
Others, please specify:
*Security Code
Enter the security code.


Site Map l   Privacy Policy l Company Profile l Corporate Proposal l Contact Us l Help l Advertise With Us l  World Trade Link
    .