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Lurasidone intermediate cas 2746-19-2 

  Category : Chemicals->active pharmaceutical ingredient

     
Lurasidone intermediate cas 2746-19-2
       

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  Country  CN

 

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Chemical&nbsp;Name: CIS-5-NORBORNENE-EXO-2,3-DICARBOXYLIC&nbsp;ANHYDRIDE<br />
Molecular&nbsp;Formula: C9H8O3<br />
Formula&nbsp;Weight: 164.16<br />
CAS&nbsp;No.: 2746-19-2
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&nbsp;<img src="http://i.bosscdn.com/product/3d/05/10/4f12a787b97185f30f06d76f30.gif" title="2746-19-2" alt="2746-19-2" />
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<span style="font-family:Times New Roman , stixgeneral, serif;font-size:15.9991px;background-color:#FFFFFF;">Lurasidone is a novel antipsychotic agent approved for the treatment of schizophrenia in a number of countries including the UK, and is also approved in the USA and Canada for the treatment of major depressive episodes associated with bipolar I disorder as either a monotherapy or adjunctive therapy with lithium or valproate. In addition to full antagonist activity at dopamine D</span><span style="font-size:0.8461em;line-height:1.6363em;vertical-align:baseline;font-family:Times New Roman , stixgeneral, serif;background-color:#FFFFFF;">2</span><span style="font-family:Times New Roman , stixgeneral, serif;font-size:15.9991px;background-color:#FFFFFF;">&nbsp;(</span><em>K</em><span style="font-size:0.8461em;line-height:1.6363em;vertical-align:baseline;font-family:Times New Roman , stixgeneral, serif;background-color:#FFFFFF;">i(D2)</span><span style="font-family:Times New Roman , stixgeneral, serif;font-size:15.9991px;background-color:#FFFFFF;">&nbsp;= 1 nM) and serotonin 5-HT</span><span style="font-size:0.8461em;line-height:1.6363em;vertical-align:baseline;font-family:Times New Roman , stixgeneral, serif;background-color:#FFFFFF;">2</span><span style="font-family:Times New Roman , stixgeneral, serif;font-size:15.9991px;background-color:#FFFFFF;">A (</span><em>K</em><span style="font-size:0.8461em;line-height:1.6363em;vertical-align:baseline;font-family:Times New Roman , stixgeneral, serif;background-color:#FFFFFF;">i(5-HT<span style="font-size:0.8461em;line-height:1.6363em;vertical-align:baseline;">2</span>A)</span><span style="font-family:Times New Roman , stixgeneral, serif;font-size:15.9991px;background-color:#FFFFFF;">&nbsp;= 0.5 nM) receptors, the pharmacodynamic profile of lurasidone is notable for its high affinity for serotonin 5-HT7 receptors (</span><em>K</em><span style="font-size:0.8461em;line-height:1.6363em;vertical-align:baseline;font-family:Times New Roman , stixgeneral, serif;background-color:#FFFFFF;">i(5-HT<span style="font-size:0.8461em;line-height:1.6363em;vertical-align:baseline;">7</span>)</span><span style="font-family:Times New Roman , stixgeneral, serif;font-size:15.9991px;background-color:#FFFFFF;">&nbsp;= 0.5 nM) and its partial agonist activity at 5-HT</span><span style="font-size:0.8461em;line-height:1.6363em;vertical-align:baseline;font-family:Times New Roman , stixgeneral, serif;background-color:#FFFFFF;">1</span><span style="font-family:Times New Roman , stixgeneral, serif;font-size:15.9991px;background-color:#FFFFFF;">A receptors (</span><em>K</em><span style="font-size:0.8461em;line-height:1.6363em;vertical-align:baseline;font-family:Times New Roman , stixgeneral, serif;background-color:#FFFFFF;">i(5-HT<span style="font-size:0.8461em;line-height:1.6363em;vertical-align:baseline;">1</span>A)</span><span style="font-family:Times New Roman , stixgeneral, serif;font-size:15.9991px;background-color:#FFFFFF;">&nbsp;= 6.4 nM). Long-term treatment of schizophrenia with lurasidone has been shown to reduce the risk of relapse. Lurasidone appears associated with minimal effects on body weight and low risk for clinically meaningful alterations in glucose, lipids or electrocardiogram parameters.</span>
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