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Imatinib Mesilate api cas 220127-57-1 cas 152459-95-5 

  Category : Chemicals->Pharmaceutical->pharmaceutical

     
Imatinib Mesilate api cas 220127-57-1 cas 152459-95-5
       

  Product Specification
 
  Country  CN

 

    Product Detail
  <table class="mbox" style="width:450px;font-size:12px;padding:0px;font-family:Arial, Helvetica, sans-serif;color:#000000;">
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<span>Chemical Name:</span>
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<a class="blue">Imatinib</a>
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<td width="120px" align="right" style="font-size:13px;font-family:arial;">
<span>Molecular Formula:</span>
</td>
<td style="font-size:13px;font-family:arial;">
C29H31N7O
</td>
</tr>
<tr>
<td width="120px" align="right" style="font-size:13px;font-family:arial;">
<span>Formula Weight:</span>
</td>
<td style="font-size:13px;font-family:arial;">
493.6
</td>
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<tr>
<td width="120px" align="right" style="font-size:13px;font-family:arial;">
<span>CAS No.:</span>
</td>
<td style="font-size:13px;font-family:arial;">
<span>152459-95-5</span>
</td>
</tr>
</tbody>
</table>
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Product Name: Imatinib Mesilate
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CAS NO: 220127-57-1
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Standard: Enterprise Standard
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Molecular Formula: C30H35N7O4S
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Molecular Weight : 589.71
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Description: White crystal or crystalline powder
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Package :25KG/drums
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Chemical names, synonyms:
</p>
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<br />
</p>
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4-[(4-methyl-1-piperazinyl)methyl]-n-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide monomethanesulfonate, STI-571, IMATINIB BASE(IMA-3), Imatinib (STI-571) Mesylate
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Minimum purity: 99%
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&nbsp;<img src="http://i.bosscdn.com/product/f9/04/9c/5d597bfc98fb61a1e417d722b0.gif" width="294" height="149" title="Imatinib Mesilate 220127-57-1" alt="Imatinib Mesilate 220127-57-1" />
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&nbsp;
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&nbsp;
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Description
</p>
<p class="MsoNormal">
White to off-white Crystalline Powder
</p>
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Identification By IR
</p>
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IR spectrum of the sample should concordant to the standard spectrum.
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Solubility
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Soluble in Water
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LOD
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NMT &nbsp;0.5% w/w
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Related substance
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by HPLC
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Single Max. Imp &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;: NMT &nbsp;0.1 %
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Total Max Imp &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;: NMT &nbsp;1.0 %
</p>
<p class="MsoNormal">
Assay (By HPLC)
</p>
<p class="MsoNormal">
NMT 98.0% And NLT 102 %
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ROI
</p>
<p class="MsoNormal">
NMT &nbsp;0.5%
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Heavy metals
</p>
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NMT 0.5%
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Thermo gram
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<p class="MsoNormal">
220-227<span>º</span><span>C</span>
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Imatinib Mesylate is a targeted therapy. Imatinib Mesylate is classified as a signal transduction inhibitor - protein-tyrosine kinase inhibitor.
</p>
<p class="MsoNormal">
A methanesulfonate (mesylate) salt that is the monomesylate salt of imatinib. Used for treatment of chronic myelogenous leukemia and gastrointestinal stromal tumours.
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Imatinib mesylate (also called Gleevec) is a small-molecule inhibitor of the fusion protein Bcr-Abl, the causal agent in chronic myelogenous leukemia.
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As an inhibitor of PDGFR, imatinib mesylate appears to have utility in the treatment of a variety of dermatological diseases. Imatinib has been reported to be an effective treatment for FIP1L1-PDGFRalpha+ mast cell disease, hypereosinophilic syndrome, and dermatofibrosarcoma protuberans.
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</div>pharmachemm.com

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