Epothilone B->Active Pharmaceutical Ingredients

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Epothilone B

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Chemicals->Import-export - chemicals and pharmaceuticals->Active Pharmaceutical Ingredients

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A compound isolated from the myxobacterium Sorangium cellulosum. Similar to paclitaxel, epothilone B induces microtubule polymerization and stabilizes microtubules against depolymerization conditions. In addition to promoting tubulin polymerization and stabilization of microtubules, this agent is cytotoxic for cells overexpressing P-glycoprotein, a characteristic that distinguishes it from the taxanes. Epothilone B may cause complete cell-cycle arrest.

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