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[CN] hydroxypropyl-beta-cyclodextrin May 27, 2022

Product Description
Hydroxypropyl-beta-cyclodextrin also named Hydroxypropyl Betadex which is the hydroxyalkylation derivative of Beta Cyclodextrin. Hydroxypropyl Betadex is non-toxic and has no side-effect. Due to its unique structure, it can improve the solubility of drugs, and making the insoluble and the indissolvable drugs dissolved in water. Consequently, it can effectively improve the bioavailability of drugs, and significantly increase the quality of medicine and dosage form. And it is widely used in the development and manufacture of new drugs.

There has been intensive and deep research on the quality, manufacturing process, stability, pharmacology, toxicology, teratogenesis, mutagenesis, carcinogenicity, hemolysis, irritation and other aspects in world, and has obtained accurate evaluation of its safety. It is safe to conclude that derivative of cyclodextrin is the pharmaceutic excipients received the most intensive research, having the most comprehensive information, and having the highest value in medicine excipients.

Product Name:

2-Hydroxypropyl-β-cyclodextrin

Synonyms:

Hydroxypropyl beta cyclodextrin aqueous solution;

Injection grade hydroxypropyl betadex;

Pharmaceutical grade hydroxypropyl betadex;

Technical grade hydroxypropyl beta cyclodextrin;

HPBCD/(2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN;

beta-hydroxypropylcyclodextrin;

(2-HYDROXYPROPYL)-BETA-CYCLODEXTRIN;

(2-Hydroxypropyl)-β-cyclodextrin

CAS:

128446-35-5

MW:

1541.54

Product Categories:

Biochemistry;Cyclodextrins;Functional Materials;Macrocycles for Host-Guest Chemistry;Oligosaccharides;Sugars;Chelation/Complexation Compounds;Synthetic Reagents;CyclodextrinsCell Culture;CyclodextrinsSynthetic Reagents;Cell Signaling and Neuroscience;Lipids and Lipid Carriers;Reagents and Supplements;Signal Transduction Research Tools;Carbohydrates & Derivatives;Other APIs

Mol File:

128446-35-5.mol

2-Hydroxypropyl-β-cyclodextrin Chemical Properties

Melting point

278 °C (dec.)

refractive index

125 ° (C=1, H2O)

storage temp.

2-8°C

solubility

H2O: 45 % (w/v)

form

solution (clear, colorless)

color

White to slightly yellow

optical activity

[α]26/D +139°, c = 1 in H2O

Water Solubility

Soluble in water.

EPA Substance Registry System

beta.-Cyclodextrin, 2-hydroxypropyl ethers (128446-35-5)

2-Hydroxypropyl-β-cyclodextrin Usage And Synthesis



Chemical Properties

White to slightly yellow powder

Chemical Properties

Hydroxypropyl betadex occurs as a white or almost white, amorphous or crystalline powder.

Uses

2-Hydroxypropyl-β-cyclodextrin (HBC) is a widely used modified cyclodextrin, the lipophilic cavity formed by 7 glucose units. Drug solubility in water is greatly enhanced by complexing with 2-Hydroxypropyl-β-cyclodextrin.

Uses

enteric coating, sustained release formulations, buccal and transdermal drug delivery

Uses

2-Hydroxypropyl-β-cyclodextrin can be used as selective estrogen receptor modulator for the prevention of osteoporosis

Production Methods

Hydroxypropyl betadex is prepared by the treatment of an alkaline solution of b-cyclodextrin with propylene oxide. The substitution pattern can be influenced by varying the pH. Formation of O-6 and O-2 substituted products is favored by high and low alkali concentration, respectively. The mixture of products produced may be refined by preparative chromatography.

Pharmaceutical Applications

Hydroxypropyl betadex has been widely investigated in pharmaceutics and has principally been used as a solubilizer for hydrophobic molecules in oral liquids,oral solids, parenterals, pressurized metered dose inhalers, dry powder inhalers, and topical formulations. It has also been shown to act as a stabilizer during processing and storage of formulations.
Hydroxypropyl betadex inclusion complexes have been reported to show mechanical properties distinct from the pure materials. The reported advantage of hydroxypropyl betadex over unsubstituted b-cyclodextrin is its greater water solubility.

Safety

The pharmaceutical toxicology of hydroxypropyl betadex has been reviewed, and in general, the material was found to be of low toxicity. It has been suggested that hydroxypropyl betadex may have a synergistic toxic effect with, for example, carcinogens, by increasing their solubility and thus bioavailability.

storage

Store in well-closed containers.

Regulatory Status

Included in oral and parenteral medicinal products. Included in an injectable preparation licensed in the UK for intramuscular or intravenous administration.

Company Profile
Company: 
SHANDONG XINDA FINE CHEMICAL CO.,LTD (click to show company details)
Contact:  Toney Hao
URL:  ***************************
Email:  Contact us
Phone:  **************
Fax:  **************
Country:  [CN]
Address:  No.2 Road Jiangong



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